How Cialis operates? (Action of Cialis).

Author: doctor | Category: Generic cialis | 24-05-2010

Cialis is strong, selective inhibitor returnable action cyclic PDE5. The main stage in penis erection is the relaxation of cages of smooth muscles corpus cavernosum which acetylcholine and nitrogen oxcide, and also other physiological agents locally call.


Acetylcholine allocate neurons parasympathetic nervous system. Nitrogen oxide make hormonal stimulation. The net effect eliminates tone of sympathetic nervous system or alpha stimulation which calls reductions of cages of smooth muscles and the penis in not excited condition saves.
Cyclic cGMF and PDE5 play the important role in normalization of erection function. CGMF calls expansion of arteries and strengthens blood inflow in corpus cavernosum. As a result pressing veins the penis becomes firm. When erections fabrics will enough increase in volume, veins corpus cavernosum are pressed.
These reduces outflow of blood from penis, and blood remains in corpus cavernosum, keeping penis in condition of erecion. Enzyme PDE5 calls splitting cGMF and the termination of erection.
Cialis oppresses activity PDE5, postponing thus splitting GMF. As a result of it level cGMF in corpus cavernosum gives to men possibility to carry out his penis in sexual intercourse.

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